Spironolactone weight loss: Does it really work?

If you are looking for weight loss solutions, you may have seen spironolactone mentioned online. Some people say it causes weight loss, others say weight gain.

The short answer: spironolactone is not a weight loss drug. Any drop on the scale is mostly water, and it comes back.

Spironolactone is a prescription "water pill," or diuretic. It helps the kidneys remove extra water and sodium through urine while holding on to potassium. It is not a supplement, and you need a doctor's prescription to take it.

It works by blocking the hormone aldosterone. That is why it is called a potassium-sparing diuretic.

According to MedlinePlus, it is used to treat high blood pressure, heart failure, hyperaldosteronism (too much aldosterone), low potassium, and swelling caused by liver or kidney disease.

Spironolactone Weight Loss

Spironolactone is approved by the U.S. Food and Drug Administration, but not for weight loss. No research has shown that it causes fat loss.

Because it removes extra fluid, people who are retaining water may see the scale drop. That is water weight, not fat.

The lost water can return once you stop the drug or your fluid levels settle. Removing too much fluid can also cause dehydration.

There is no "weight loss dose" of spironolactone. Only your doctor should decide whether you take it and how much.

Spironolactone and Weight Gain

There is little evidence that Spironolactone causes weight gain. MedlinePlus does not list weight gain among its side effects.

Common side effects include stomach upset, diarrhea, drowsiness, breast tenderness or enlargement, and irregular periods. Tell your doctor if any side effect is severe or does not go away.

If spironolactone is being used to treat fluid buildup and the condition gets worse, you can gain weight from the retained fluid. Sudden weight gain or swelling while on a diuretic is a reason to call your doctor.

Does it really work?

For fat loss, no. Spironolactone can flush out extra fluid in people who are retaining it, which may make the scale drop for a short time.

That is not a healthy or lasting way to lose weight. The CDC recommends gradual loss of about 1 to 2 pounds a week through diet and activity, and there are many practical dieting tips to help.

Some users report gaining weight while taking it, but that has not been shown to be caused by the drug. Diet, activity and the underlying health condition all play a role.

Normal, healthy weight loss through good nutrition and regular exercise cannot be compared to this technique, which is a kind of water weight loss.

Do not take spironolactone to change your weight. It is meant for treating specific medical conditions.

Spironolactone Reviews for Weight Loss

User reviews online are mixed. Some people report losing water weight and others report gaining weight, but reviews are not clinical evidence.

Many people take spironolactone for off-label reasons, such as acne, hair loss or excess facial hair in women. These uses are prescribed by a doctor and are not about weight.

Serious side effects can happen. MedlinePlus lists muscle weakness or cramps, changes in heartbeat, confusion, signs of dehydration, and decreased urination among those that need prompt medical attention.

Spironolactone can raise potassium to dangerous levels. Avoid potassium supplements and potassium-based salt substitutes unless your doctor approves them.

FAQS

What is Spironolactone?

Spironolactone is a prescription "water pill," a potassium-sparing diuretic. It is mainly used to treat high blood pressure, heart failure and fluid buildup.

Can it be used for the treatment of hyperaldosteronism?

Yes. Hyperaldosteronism means the adrenal glands make too much aldosterone, and spironolactone blocks that hormone. It also helps the body hold on to potassium.

How many pounds/kgs can one lose when on Spironolactone?

There is no reliable figure, because spironolactone is not a weight loss drug. Any loss is mostly water and usually returns.

How do I take spironolactone at what intervals?

It comes as a tablet or liquid and is usually taken once or twice a day at about the same time each day. Take it the same way each time, either always with food or always without. Always follow your doctor's directions.

Does spironolactone really work?

It works well for the conditions it is prescribed for. It does not cause fat loss.

What if I take Spironolactone while nursing Kidney problems?

Tell your doctor if you have kidney disease. Spironolactone can raise potassium levels, and it may not be safe for some people with kidney problems.

Does Spironolactone really have effects on body weight?

It can lower water weight in people who retain fluid. It has not been shown to cause lasting fat loss or weight gain.

Conclusion

Spironolactone is not a weight loss drug. Because it removes extra fluid, some people see a temporary drop on the scale.

It is approved to treat conditions such as high blood pressure, heart failure, hyperaldosteronism and fluid buildup from liver or kidney disease. It has side effects, including high potassium.

Spironolactone is a prescription medicine. Without the consultation of a doctor, taking it is not safe, and it should never be used to lose weight.

Sources

• Spironolactone: MedlinePlus Drug Information, MedlinePlus (NIH)
• Steps for Losing Weight, CDC